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Pass the Clinical Biochemical Genetics exam with confidence.

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1000+CBG Questions
15Exam Domains
10Free Questions
2026Updated
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Practice expert-vetted questions, find your weak domains, and turn every mistake into a focused review plan.

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Study by domain

Practice the CBG exam by domain

1. Amino acids (15%) — PKU and hyperphenylalaninemia; Tyrosinemias; Glycine encephalopathy/hyperglycinemia; MSUD and disorders of branched-chain amino acids; Homocystinuria/disorders of sulfur amino acids and re-methylation; Urea cycle defects; Other/Serine

Key exam domain

Identify weak areas and improve with focused review.

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2. Organic acids (12%) — Methylmalonic acidemia (excluding cobalamin defects) and propionic acidemia; 3-MCC deficiency and other C5OH-related disorders including 3-MCC deficiency and other C5OH-related disorders; IVA and other C5-related disorders; Glutaric acidemia type I; Disorders of ketone body metabolism (HMG-CoA lyase, SCOT); Other including Glutathione synthetase deficiency, ECHS1, and 3-methylglutaconic aciduria non-type 1

Key exam domain

Identify weak areas and improve with focused review.

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3. Cofactors (7%) — Cobalamin; Biotin; Molybdenum; Folate; Pyridoxine; Biopterin; Other including riboflavin, niacin, and thiamine

Key exam domain

Identify weak areas and improve with focused review.

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4. Carbohydrates (10%) — Glycogenoses (except GSD II [see LSD]); Disorders of glycolysis; Disorders of gluconeogenesis including fructose-1,6-bisphosphatase deficiency; Disorders of Galactose metabolism; Disorders of fructose metabolism; Congenital disorders of glycosylation; Other including pentose phosphate

Key exam domain

Identify weak areas and improve with focused review.

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5. Lipids (13%) — Fatty acid oxidation disorders including short-chain, medium-chain, long-chain, and multiple acyl-CoA dehydrogenase deficiency (GA2); Hyperlipidemias including Tangier disease and other; Disorders of cholesterol metabolism including Smith-Lemli-Opitz, Niemann-Pick C, and other bile acid disorders

Key exam domain

Identify weak areas and improve with focused review.

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6. Lysosomes (12%) — Mucopolysaccharidoses including Type I, Type II, Type III, Type IV, Type VI, and Type VII; Sphingolipidoses including Gaucher disease, Fabry disease, GM2 gangliosidoses including Tay-Sachs disease and variants and Sandhoff disease, Krabbe disease, Niemann Pick types A and B, GM1 gangliosidosis, and other; Multiple enzyme deficiencies including Mucolipidoses ML-II and ML-III, Multiple sulfatase deficiency, and other; Other including Pompe, Cystinosis, and NCL

Key exam domain

Identify weak areas and improve with focused review.

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7. Mitochondria (7%) — Mitochondrial myopathies with laboratory findings; Mitochondrial myopathies with Leigh syndrome; Mitochondrial myopathies with adult presentations; Disorders of electron transport chain function and assembly; Mitochondrial DNA mutation disorders; Disorders of mtDNA maintenance; Mitochondrial DNA depletion syndromes; Other including MELAS

Key exam domain

Identify weak areas and improve with focused review.

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8. Peroxisomes (3%) — Biogenesis disorders including Zellweger syndrome; Single-enzyme disorders including X-linked adrenoleukodystrophy; Other including Refsum - infantile

Key exam domain

Identify weak areas and improve with focused review.

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9. Purines and pyrimidines (3%) — Purine disorders including Lesch-Nyhan disease, Adenosine deaminase deficiency, and other; Pyrimidine disorders including UMP synthase deficiency and other

Key exam domain

Identify weak areas and improve with focused review.

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10. Transport (3%) — Dibasic aminoaciduria including cystinuria and lysinuric protein intolerance; Other amino acid transport disorders; Glucose; Carnitine; Other

Key exam domain

Identify weak areas and improve with focused review.

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11. Creatine

1% of the exam

Identify weak areas and improve with focused review.

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12. Neurotransmitters (2%) — Succinic semialdehyde dehydrogenase (SSADH) deficiency; Disorders of dopamine synthesis; Other including GABA metabolism

Key exam domain

Identify weak areas and improve with focused review.

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13. Metals (3%) — Copper including Wilson disease, Menkes disease, and other; Iron; Zinc; Other

Key exam domain

Identify weak areas and improve with focused review.

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14. Laboratory (8%) — QA/QC; Artifact; Techniques; Regulations

Key exam domain

Identify weak areas and improve with focused review.

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15. Other disease category

3% of the exam

Identify weak areas and improve with focused review.

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Frequently asked questions

Straight answers about the CBG exam, the questions, pricing, the free trial, and how this fits your prep.

The CBG exam spans 15 domains - Amino acids (15%) — PKU and hyperphenylalaninemia; Tyrosinemias; Glycine encephalopathy/hyperglycinemia; MSUD and disorders of branched-chain amino acids; Homocystinuria/disorders of sulfur amino acids and re-methylation; Urea cycle defects; Other/Serine, Organic acids (12%) — Methylmalonic acidemia (excluding cobalamin defects) and propionic acidemia; 3-MCC deficiency and other C5OH-related disorders including 3-MCC deficiency and other C5OH-related disorders; IVA and other C5-related disorders; Glutaric acidemia type I; Disorders of ketone body metabolism (HMG-CoA lyase, SCOT); Other including Glutathione synthetase deficiency, ECHS1, and 3-methylglutaconic aciduria non-type 1, Cofactors (7%) — Cobalamin; Biotin; Molybdenum; Folate; Pyridoxine; Biopterin; Other including riboflavin, niacin, and thiamine, Carbohydrates (10%) — Glycogenoses (except GSD II [see LSD]); Disorders of glycolysis; Disorders of gluconeogenesis including fructose-1,6-bisphosphatase deficiency; Disorders of Galactose metabolism; Disorders of fructose metabolism; Congenital disorders of glycosylation; Other including pentose phosphate, Lipids (13%) — Fatty acid oxidation disorders including short-chain, medium-chain, long-chain, and multiple acyl-CoA dehydrogenase deficiency (GA2); Hyperlipidemias including Tangier disease and other; Disorders of cholesterol metabolism including Smith-Lemli-Opitz, Niemann-Pick C, and other bile acid disorders, Lysosomes (12%) — Mucopolysaccharidoses including Type I, Type II, Type III, Type IV, Type VI, and Type VII; Sphingolipidoses including Gaucher disease, Fabry disease, GM2 gangliosidoses including Tay-Sachs disease and variants and Sandhoff disease, Krabbe disease, Niemann Pick types A and B, GM1 gangliosidosis, and other; Multiple enzyme deficiencies including Mucolipidoses ML-II and ML-III, Multiple sulfatase deficiency, and other; Other including Pompe, Cystinosis, and NCL, Mitochondria (7%) — Mitochondrial myopathies with laboratory findings; Mitochondrial myopathies with Leigh syndrome; Mitochondrial myopathies with adult presentations; Disorders of electron transport chain function and assembly; Mitochondrial DNA mutation disorders; Disorders of mtDNA maintenance; Mitochondrial DNA depletion syndromes; Other including MELAS, Peroxisomes (3%) — Biogenesis disorders including Zellweger syndrome; Single-enzyme disorders including X-linked adrenoleukodystrophy; Other including Refsum - infantile, Purines and pyrimidines (3%) — Purine disorders including Lesch-Nyhan disease, Adenosine deaminase deficiency, and other; Pyrimidine disorders including UMP synthase deficiency and other, Transport (3%) — Dibasic aminoaciduria including cystinuria and lysinuric protein intolerance; Other amino acid transport disorders; Glucose; Carnitine; Other, Creatine (1%), Neurotransmitters (2%) — Succinic semialdehyde dehydrogenase (SSADH) deficiency; Disorders of dopamine synthesis; Other including GABA metabolism, Metals (3%) — Copper including Wilson disease, Menkes disease, and other; Iron; Zinc; Other, Laboratory (8%) — QA/QC; Artifact; Techniques; Regulations, and Other disease category (3%). Every practice question maps to one of them, so you train on exactly what's tested.

No - and that matters. These are original practice questions written to mirror the style, difficulty, and domain coverage of the CBG exam blueprint. We never distribute actual exam content, so practicing here keeps you fully compliant with official exam policies.

No. CBG Exam Prep is an independent study resource for Clinical Biochemical Genetics (CBG). It is not affiliated with, sponsored by, or endorsed by the official certifying body or exam administrator.

What candidates say

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Real feedback from CBG candidates on Reddit.

★★★★★
Sourced from Reddit

"put off studying the organic acidemias section for weeks ngl, kept mixing up propionic and methylmalonic workups. the practice sets on clinicalbiochemicalexam.com finally made it stick. passed on my first try, still kinda surprised."

r/genetics Posted on Reddit
★★★★★
Sourced from Reddit

"honestly wasnt sure a question bank could help with something this niche but it did. mistake review after each block showed me i kept blanking on the same mito disorders, fixed that in the last two weeks before the exam."

r/medicine Posted on Reddit
★★★★★
Sourced from Reddit

"behind all through fellowship, barely studied until a month out. the mock exams gave me a realistic sense of pacing and the lysosomal storage questions actually resembled real ones. recieved my pass letter last week, relieved more than anything."

r/Residency Posted on Reddit

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