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CBG practice questions - frequently asked questions

Plain answers about how CBG Exam Prep works: the exam, the questions, pricing, the free trial, and what you actually get.

No - and you should be wary of any site claiming otherwise. Every question here is original, written to mirror the style, difficulty, and judgment the real CBG exam tests. Each one comes with a plain-language explanation of why the right answer is right and the others aren't.

The CBG exam spans 15 domains: Amino acids (15%) — PKU and hyperphenylalaninemia; Tyrosinemias; Glycine encephalopathy/hyperglycinemia; MSUD and disorders of branched-chain amino acids; Homocystinuria/disorders of sulfur amino acids and re-methylation; Urea cycle defects; Other/Serine; Organic acids (12%) — Methylmalonic acidemia (excluding cobalamin defects) and propionic acidemia; 3-MCC deficiency and other C5OH-related disorders including 3-MCC deficiency and other C5OH-related disorders; IVA and other C5-related disorders; Glutaric acidemia type I; Disorders of ketone body metabolism (HMG-CoA lyase, SCOT); Other including Glutathione synthetase deficiency, ECHS1, and 3-methylglutaconic aciduria non-type 1; Cofactors (7%) — Cobalamin; Biotin; Molybdenum; Folate; Pyridoxine; Biopterin; Other including riboflavin, niacin, and thiamine; Carbohydrates (10%) — Glycogenoses (except GSD II [see LSD]); Disorders of glycolysis; Disorders of gluconeogenesis including fructose-1,6-bisphosphatase deficiency; Disorders of Galactose metabolism; Disorders of fructose metabolism; Congenital disorders of glycosylation; Other including pentose phosphate; Lipids (13%) — Fatty acid oxidation disorders including short-chain, medium-chain, long-chain, and multiple acyl-CoA dehydrogenase deficiency (GA2); Hyperlipidemias including Tangier disease and other; Disorders of cholesterol metabolism including Smith-Lemli-Opitz, Niemann-Pick C, and other bile acid disorders; Lysosomes (12%) — Mucopolysaccharidoses including Type I, Type II, Type III, Type IV, Type VI, and Type VII; Sphingolipidoses including Gaucher disease, Fabry disease, GM2 gangliosidoses including Tay-Sachs disease and variants and Sandhoff disease, Krabbe disease, Niemann Pick types A and B, GM1 gangliosidosis, and other; Multiple enzyme deficiencies including Mucolipidoses ML-II and ML-III, Multiple sulfatase deficiency, and other; Other including Pompe, Cystinosis, and NCL; Mitochondria (7%) — Mitochondrial myopathies with laboratory findings; Mitochondrial myopathies with Leigh syndrome; Mitochondrial myopathies with adult presentations; Disorders of electron transport chain function and assembly; Mitochondrial DNA mutation disorders; Disorders of mtDNA maintenance; Mitochondrial DNA depletion syndromes; Other including MELAS; Peroxisomes (3%) — Biogenesis disorders including Zellweger syndrome; Single-enzyme disorders including X-linked adrenoleukodystrophy; Other including Refsum - infantile; Purines and pyrimidines (3%) — Purine disorders including Lesch-Nyhan disease, Adenosine deaminase deficiency, and other; Pyrimidine disorders including UMP synthase deficiency and other; Transport (3%) — Dibasic aminoaciduria including cystinuria and lysinuric protein intolerance; Other amino acid transport disorders; Glucose; Carnitine; Other; Creatine (1% of the exam); Neurotransmitters (2%) — Succinic semialdehyde dehydrogenase (SSADH) deficiency; Disorders of dopamine synthesis; Other including GABA metabolism; Metals (3%) — Copper including Wilson disease, Menkes disease, and other; Iron; Zinc; Other; Laboratory (8%) — QA/QC; Artifact; Techniques; Regulations; Other disease category (3% of the exam). Every practice question on this site is tagged to one of these domains.

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